Tuesday, August 25, 2020

Mill Essay Example For Students

Factory Essay At the point when confronted with an ethical situation, utilitarianism distinguishes the suitable contemplations, yet offers no reasonable method to assemble the fundamental data to make the necessary figurings. This absence of data is an issue both in assessing the government assistance issues and inevaluating the consequentialist issues which utilitarianism requiresbe weighed when settling on moral choices. Utilitarianism endeavors tosolve both of these challenges by engaging experience; however,no strategy for accommodating an individual choice with the standards ofexperience is recommended, and no relative loads are relegated to thevarious contemplations. In choosing whether or not to torment a fear based oppressor who has planted a bomb in New York City, an utilitarian must assess both the general government assistance of the individuals in question or affected by the activity taken, and the outcomes of the activity taken. To figure the government assistance of the individuals engaged with or affected by an activity, utilitarianism necessitates that all people be considered similarly. Quantitative utilitarians would gauge the delight and agony which would be brought about by the bomb detonating against the pleasureand torment that would be brought about by tormenting the psychological oppressor. At that point, the sums would be added and analyzed. The issue with this strategy is that it is difficult to realize previously how much torment would be brought about by the bomb detonating or how much torment would be brought about by the torment. Utilitarianism offers no down to earth approach to make the relational correlation of utility important to look at the torments. On account of the bomb detonating, it in any event appears to be exceptionally plausible that a more prominent measure of torment would be caused, at any rate in the present, by the bomb detonating. This likelihood gets the job done for a quantitative utilitarian, however it doesn't represent the outcomes, which make a completely extraordinary issue, which will be talked about underneath. The likelihood additionally doesn't hold for Mills utilitarianism. Factories Utilitarianism demands subjective utilitarianism, which necessitates that one consider the measure of agony or joy, yet in addition the nature of such torment and delight. Plant recommends that to recognize various torments and delights we ought to ask individuals who have encountered the two kinds which is increasingly pleasurable or progressively difficult. This arrangement doesn't work for the topic of torment contrasted with death in a blast. There is nobody who has encountered both, along these lines, there is nobody who can be counseled. Regardless of whether we concur that the agony brought about by the quantity of passings in the blast is more prominent than the torment of the fear based oppressor being tormented, this appraisal just records for the government assistance half of the utilitarians contemplations. Moreover, one has no real way to gauge the amount more agony is brought about by permitting the bomb to detonate than by tormenting the psychological oppressor. In the wake of settling the issues encompassing the government assistance, an utilitarian should likewise think about the outcomes of an activity. In gauging the outcomes, there are two significant contemplations. The primary, which is particularly imperative to objectivist Utilitarianism, is which individuals will be executed. The second is the point of reference which will be set by the activity. Shockingly for the chief, the data important to make both of these computations is inaccessible. It is highly unlikely to figure out which individuals will be executed and gauge whether their demises would be useful for society. Utilitarianism necessitates that one think about the decency that the individuals would accomplish for society with the damage they would do society on the off chance that they were not murdered. For instance, if a youthful Adolf Hitler were in the structure, it may accomplish all the more useful for society to permit the structure to detonate. Sadly for an individual endeavoring to utilize utilitarianism to settle on for choices, it is extremely unlikely to know in advance what an individual will do. .ufd9675a6de0a873df4bf05cec5565dee , .ufd9675a6de0a873df4bf05cec5565dee .postImageUrl , .ufd9675a6de0a873df4bf05cec5565dee .focused content zone { min-stature: 80px; position: relative; } .ufd9675a6de0a873df4bf05cec5565dee , .ufd9675a6de0a873df4bf05cec5565dee:hover , .ufd9675a6de0a873df4bf05cec5565dee:visited , .ufd9675a6de0a873df4bf05cec5565dee:active { border:0!important; } .ufd9675a6de0a873df4bf05cec5565dee .clearfix:after { content: ; show: table; clear: both; } .ufd9675a6de0a873df4bf05cec5565dee { show: square; progress: foundation shading 250ms; webkit-change: foundation shading 250ms; width: 100%; mistiness: 1; progress: obscurity 250ms; webkit-change: murkiness 250ms; foundation shading: #95A5A6; } .ufd9675a6de0a873df4bf05cec5565dee:active , .ufd9675a6de0a873df4bf05cec5565dee:hover { darkness: 1; progress: haziness 250ms; webkit-progress: obscurity 250ms; foundation shading: #2C3E50; } .ufd9675a6de0a873df4bf05cec5565dee .focused content zone { width: 100%; position: relative; } .ufd9675a6de0a873df4bf05cec5565dee .ctaText { outskirt base: 0 strong #fff; shading: #2980B9; text dimension: 16px; textual style weight: intense; edge: 0; cushioning: 0; text-enrichment: underline; } .ufd9675a6de0a873df4bf05cec5565dee .postTitle { shading: #FFFFFF; text dimension: 16px; text style weight: 600; edge: 0; cushioning: 0; width: 100%; } .ufd9675a6de0a873df4bf05cec5565dee .ctaButton { foundation shading: #7F8C8D!important; shading: #2980B9; fringe: none; outskirt sweep: 3px; box-shadow: none; text dimension: 14px; textual style weight: striking; line-tallness: 26px; moz-fringe span: 3px; text-adjust: focus; text-design: none; text-shadow: none; width: 80px; min-tallness: 80px; foundation: url(https://artscolumbia.org/wp-content/modules/intelly-related-posts/resources/pictures/straightforward arrow.png)no-rehash; position: outright; right: 0; top: 0; } .ufd9675a6de0a873df4bf05cec5565dee:hover .ctaButton { foundation shading: #34495E!important; } .ufd9675a6de0a873df4bf0 5cec5565dee .focused content { show: table; tallness: 80px; cushioning left: 18px; top: 0; } .ufd9675a6de0a873df4bf05cec5565dee-content { show: table-cell; edge: 0; cushioning: 0; cushioning right: 108px; position: relative; vertical-adjust: center; width: 100%; } .ufd9675a6de0a873df4bf05cec5565dee:after { content: ; show: square; clear: both; } READ: GEOLOGY 170 REPORT: Essay Furthermore, without realizing which fabricating the bomb is in, it is highly unlikely to foresee which individuals will most likely be in the structure. A subjectivist utilitarian would excuse this thought and would inspect just what a discerning individual would consider to be the outcome; in any case, even the subjectivist utilitarian must face the topic of point of reference setting. Utilitarianism believes equity and others conscious treatment to be useful for society all in all and in this manner instrumentally great as a way to advancing joy. Utilitarianism believes point of reference to be

Saturday, August 22, 2020

MGT499-Module 5 Case

MGT499-Module 5 Case Key MANAGEMENT: STRATEGIC CHOICES AND IMPLEMENTATIONTrident UniversityMrs. Carmen M. PâÆ'â ©rez-De La MattaModule 5 - CaseMGT499 - Strategic ManagementProfessor: Dr. Alan PreizerOctober 1, 2014Case AssignmentStrategic Choices at Harley-Davidson Motor CompanyTo complete Module 5 Case Assignment, read the data out of sight material, search for more data and survey a portion of your past readings for this class, and afterward compose a 4-to 5-page report for your educator and the officials of H-D Corporation by noting the accompanying questions:What technique (or mix of methodologies) did Harley-Davidson use to turn out to be such an effective organization?To what degree has Harley-Davidson's procedure (or mix of systems) changed throughout the years, or been constant?How does Harley-Davidson's methodology (or blend of methodologies) fit with the earth of the cruiser industry?How does Harley-Davidson's system (or mix of methodologies) fit with the inside assets and abilities of the fi rm?Based on your examination and discoveries, what might you prescribe to the administrators of Harley-Davidson Motorcycle Corporation?Note: Reports/assignments won't be acknowledged without legitimate references and references.The 1490cc HD motor. Elastic mounted.Use the sources from the foundation material along with the sources you find on your own.This paper ought to include: A presentation expressing the proposition, position, or focal subject of your paper, a principle body concentrating on the key task determinations, and an end succinctly expressing the central matters of your investigation and the ends you reached.IntroductionHarley-Davidson has been a significant U.S. cruiser maker and the main vender of heavyweight models in the American market as well as works universally, with deals for the most part in North America, Europe, Asia/Pacific and Latin America. For Harley-Davidson has been significant to make business techniques in guaranteeing the organization prevails in a various serious focused on shopper commercial center. This paper...

Thursday, July 30, 2020

Upcoming non-MIT deadlines

Upcoming non-MIT deadlines Please note: these deadlines were from 2005-2006. This years deadlines are almost certainly different. So many deadlines! Its easy to forget everything thats going on, and sometimes youre not even aware of whats out there. In that spirit, here are some deadline for some programs that MIT applicants are often interested in: Gates Millennium Scholarship: January 13 Davidson Fellows: January 13/March 15 Clay Research Academy: February 4 All-USA High School Academic Team: mid-February Also, I should make the juniors (and, for some of these programs, other students) out there aware of the deadlines for a subset of recommended summer programs (a much more complete entry on summer programs is forthcoming): State Governors Schools: deadlines processes vary AwesomeMath: April 30 (early: January 31) RSI (Research Science Institute): February 1 WTP (Womens Technology Program): February 1 MITES (Minority Introduction to Engineering Science): February 3 SSP (Summer Science Program): March 24 (early: February 24) Canada/USA Mathcamp: late April

Friday, May 22, 2020

Essay about Immigration Reform - 722 Words

Immigration Reform At this time, the United States has allowed more immigrants to enter the country than at any time in its history. Over a million legal and illegal immigrants take up residence in the United States each year. Immigration at its current magnitude is not fulfilling the interests or demands of this country. With the country struggling to support the huge intake of new comers, life in America has been suffering tremendously. The excessive stress put upon the welfare system, overuse of the family reunification laws, and the exploitation of employment based immigration in the computer industry are reasons for immigration reform. The United States welfare system has difficulties supporting the huge†¦show more content†¦These laws create a problem that researchers call chain migration. According to the FAIR organization, ?because of chain migration--one immigrant sponsors several family members as immigrants, who then sponsor several others themselves, and so on. Since chain migration began in the mid 1960s, annual immigration has tripled.? Many sponsors have not met those they have helped, or much less have the desire to be reunited with them. The laws are often used to further economic goals rather than joining families. People migrate to the United States with pipe dreams of financial securities. The high rates of family sponsored immigration from poor countries such as China and the Philippines rival those of richer countries such as Japan. Immigration reform not only has a strong following but an equally large opposition as well. The opposition argues that immigrants create job and do not take jobs from U.S. citizens. Several studies demonstrate that there is a positive relationship between states who admit immigrants and employment. One study found between 1970-1980 Mexican immigration to Los Angeles County was responsible for 78,000 new jobs. They claim that the U.S. work force, especially the computer industry, will suffer from the withdrawl of highly skilled workers. The current unemployment rates are blamed on the relocation of multinational companies overseas toShow MoreRelatedImmigration Reform2072 Words   |  9 PagesImmigration and Immigration Reform Haley Johnson Axia College of University of Phoenix Thesis Statement: More and more immigrants are coming in to the United States each year, and we as a nation should truly reevaluate our immigration policies. Immigration and Immigration Reform The number of illegal immigrants who come into the United States each year is staggering, and the numbers just keep on increasing. Three million illegal immigrants come into the United States every yearRead MoreImmigration Reform : Illegal Immigration1697 Words   |  7 Pages Back in 2007 there were several concerns over immigration as a whole and exploding proportions of illegal immigrants crossing the border in the Arizona area. Arizona attempted to resolve the influx of people across the border by imposing heavy fines on employers hiring illegal immigrants. At that time in Arizona there was a democratic governor Janet Napolitano that continually vetoed the Arizona’s legislature attempt to reduce illegal immigration. In 2009 the state replaced the Democratic governorRead MoreImmigration Reform And The Immigration Boom Essay1307 Words   |  6 Pageslook like my old town. No, it does not, I responded. Since you went to sleep, we had what you could call an immigration b oom. Now in your old town we have people from many parts of the world. What you see here is the result of immigration reforms, which helps boost the economy, create diversity, and cause cultural enrichment.† RIP if I may call you RIP let me tell you about what immigration is, better yet, let me tell you about immigrants. At the time you were living in your farm, and your prolongedRead MoreEssay on Immigration Reform750 Words   |  3 PagesImmigration Reform At this time, the United States has allowed more immigrants to enter the country than at any time in its history. Over a million legal and illegal immigrants take up residence in the United States each year. Immigration at its current magnitude is not fulfilling the interests or demands of this country. With the country struggling to support the huge intake of new comers, life in America has been suffering tremendously. The excessive stress put upon the welfare system, overuseRead MoreThe Issue Of Immigration Reform Essay1401 Words   |  6 Pages Immigration Reform Tony Smith HSE 430 November 17, 2016 Nick R. North Immigration Reform Introduction Public Opinion The American public seems to be aware of the issue in general, but is short of the details. There has certainly been a healthy amount of media coverage of immigration reform, but as the coverage itself is unclear as to how best to frame the problems, it mostly informs about the existence of the issue rather than informing about the issue itself. As such, there is conflictingRead MoreImmigration Reform Of Hispanic Immigration1987 Words   |  8 PagesImmigration of Latinos has long caused cultural conflict, especially when it comes to the illegal immigration of Latinos. Unfortunately, the issue has long been debated and there seems to be no clear cut answer on how to resolve the problem. Many Americans often overlook the struggles that Latinos endure and place stereotypes upon this group of people that are untrue. Furthermore, most Americans are misinformed or uninformed about the other side of this hot issue. The purpose of this essay is toRead MoreThe Need for Immigration Reform1 193 Words   |  5 Pagesdebate on immigration reform has been heated and often uninformed. Every president mentions in his speech to take action on immigration reform. But unfortunately he ends up taking action against immigrants by deporting them. Is the country founded by immigrants has closed doors for the immigrants? People are fighting for the immigration reform. In order for the bright future of America we need to fix the present problems. A land of opportunity has taken many hits but the immigration reform madeRead MoreThe Importance of an Immigration Reform949 Words   |  4 Pagestime for an immigration reform. A reform to stop the separation of millions of families and help heal our economy. From its origin the United States has been called a nation of immigrants. It is a melting pot for countless cultures, religions, and races. Our immigrant past has helped create a national character. Our country attracts the most brilliant people from all around the world from the highly educated to the hardworking immigrants. Unfortunately, due to the broken immigration system itRead MoreThe Debate On Immigration Reform958 Words   |  4 Pagessurrounding the Development, Relief, and Education for Alien Minors, or DREAM Act, brought about legal, ethical, and logistical concerns. Illegal immigration and the population unauthorized alien in the United States were key issues in the ongoing debate on immigration reform. However, the benefits of this bill outweighed its disadvantages. Immigration policies in the United States concerning undocumented workers are strict and direct. Employers are not allowed to employ illegal or undocumented immigrantsRead MoreImmigration Act Of 1965 An d The Immigration Reform Essay1648 Words   |  7 Pagescountless citizens to be open when it comes to immigration, while keeping the country hospitable to its citizens for generations to come. However, this attitude to immigration is a fairly recent phenomenon in American history, especially in regards to immigrants coming in from non-Western European countries. With the introduction of the Immigration Act of 1965 and the Immigration Reform and Control Act of 1986 (IRCA) came about the changes to immigration policy that would forever change the face of

Saturday, May 9, 2020

Vital Pieces of Social Issues to Write an Essay on

Vital Pieces of Social Issues to Write an Essay on Failing to plan an exit strategy is merely a single approach to sabotage your company. Grants are an essential part of running a nonprofit, but they aren't a legitimate argument for picking nonprofit status on a for-profit company. It's inportant to observe that you're able to affect and change any sort of media too, and societal networks aren't an exception. Social networking is just a way to network and utilize word of mouth, online. As an issue of fact, social media plays a massive part in the general advertisement and set up of the company. They is really picking up speed, more and more are realizing the benefits of connecting and interacting with customers and potential customers. What Is So Fascinating About Social Issues to Write an Essay on? Unless, on the flip side, the introduction is an organic portion of the post, it fails of its objective. There are social problems that haunt the education system. Generally, social science research, a scientific research, applies similar research methodologies the very same as other varieties of research like marketing research that is inherent with both quantitative strategy and qualitative strategy, clinical research that's emphasized on specific areas li ke pharmaceutical, chemical, health care research, and so forth. After all, social media has come to be an entirely incorporated system comprising a two-way stream of implementation and feedback. Basically, you've got to look for keywords. Write short and precise is our principal motto when writing the majority of the content. Consistency is crucial to generate much better results. For instance, if you're writing an essay on How Global Warming can be decreased, it'll be an excellent idea you take a minute to define what global warming is about in your introductory paragraph. The introduction or the introductory paragraph is quite a relevant facet of your essay due to the simple fact it states the principal idea of your composition. Addressing someone incorrectly will set a negative shadow over the rest of your letter. First things first, You will want to choose what type of information to have in your disclaimer. All the words will make sense in the sentences, or so the class will have to determine which answer they feel is the very best. Readers' likelihood to read the entire letter is dependent on the very first few lines. Whether it concerns the beginning of a Business letter or an informal letter, there are a couple things which you should know. Choosing Good Social Issues to Write an Essay on The cost of an essay is dependent upon the quantity of effort the writer has to exert. You've probably heard that writing articles is a significant way to promote your company. Research before you compose the essay. Before you're prepared to go public with your essay you may want to demonstrate your work to a couple of your buddies. Social Issues to Write an Essay on - the Story You check out their business Fanpage, and get started reading their tips and data about chiropractics and their small business. Customer service Customers have begun employing the social networking platform for a point of interaction with a business enterprise. If you would like to enhance your organization, you must begin with your managers. In case the business is unavailable, customers can't express their valuable experiences which impede the development of the goods. Social Issues to Write an Essay on As a consequence, once a person is labeled as deviant they could possibly be rejected by social groups like family and friends, ultimately resulting in further deviant acts. Spending just thirty minutes per day on at least one of the next steps will move you toward your target. The person is likely to forget some points. Your response should handle every one of your youngster's areas of interest and strength. Moreover, child labour isn't the demand of the society also. Generally, a society usually means a huge group of folks dwelling in a place or within a country below the control of same laws, values and culture. As per a survey by International Labour Organization, if every child throughout the world becomes proper education, it will raise the world's total income, and therefore, help to enhance the economy of each nation and make it an excellent place to reside. Many children all around the world start earning at the age which is in fact intended to play, study and learn. The writing of a disclaimer can be a tough job for somebody who has never written one before, therefore I will supply you with a succinct guide which you could use and follow. A legal statement is something which you might need to speak to a lawyer about. As its name suggests, the conclusion is where you're going to conclude. Failure to spot the appropriate emotions between people interacting in all elements of life can result in misunderstandings and conflict. In the background, there's a sample of Beethoven's Fur Elise, which sounds like it's being played by means of a novice pianist. The important thing is to make sure that when your kid is practicing, he's practicing writing letters CORRECTLY.

Wednesday, May 6, 2020

Chapter 3 The Knight Bus Free Essays

Harry was several streets away before he collapsed onto a low wall in Magnolia Crescent, panting from the effort of dragging his trunk. He sat quite still, anger still surging through him, listening to the frantic thumping of his heart. But after ten minutes alone in the dark street, a new emotion overtook him: panic. We will write a custom essay sample on Chapter 3 The Knight Bus or any similar topic only for you Order Now Whichever way he looked at it, he had never been in a worse fix. He was stranded, quite alone, in the dark Muggle world, with absolutely nowhere to go. And the worst of it was, he had just done serious magic, which meant that he was almost certainly expelled from Hogwarts. He had broken the Decree for the Restriction of Underage Wizardry so badly, he was surprised Ministry of Magic representatives weren’t swooping down on him where he sat. Harry shivered and looked up and down Magnolia Crescent. What, was going to happen to him? Would he be arrested, or would he simply be outlawed from the wizarding world? He thought of Ron and Hermione, and his heart sank even lower. Harry was sure that, criminal or not, Ron and Hermione would want to help him now, but they were both abroad, and with Hedwig gone, he had no means of contacting them. He didn’t have any Muggle money, either. There was a little wizard gold in the money bag at the bottom of his trunk, but the rest of the fortune his parents had left him was stored in a vault at Gringotts Wizarding Bank in London. He’d never be able to drag his trunk all the way to London. Unless†¦ He looked down at his wand, which he was still clutching in his hand. If he was already expelled (his heart was. now thumping painfully fast), a bit more magic couldn’t hurt. He had the Invisibility Cloak he had inherited from his father — what if he bewitched the trunk to make it feather-light, tied it to his broomstick, covered himself in the cloak, and flew to London? Then he could get the rest of his money out of his vault and†¦begin his life as an outcast. It was a horrible prospect, but he couldn’t sit on this wall forever, or he’d find himself trying to explain to Muggle police why he was out in the dead of night with a trunk full of spell books and a broomstick. Harry opened his trunk again and pushed the contents aside, looking for the Invisibility Cloak — but before he had found it, he straightened up suddenly, looking around him once more. A funny prickling on the back of his neck had made Harry feel he was being watched, but the street appeared to be deserted, and no lights shone from any of the large square houses. He bent over his trunk again, but almost immediately stood up once more, his hand clenched on his wand. He had sensed rather than heard it: someone or something was standing in the narrow gap between the garage and the fence behind him. Harry squinted at the black alleyway. If only it would move, then he’d know whether it was just a stray cat or — something else. â€Å"Lumos,† Harry muttered, and a light appeared at the end of his wand, almost dazzling him. He held it high over his head, and the pebble-dashed walls of number two suddenly sparkled; the garage door gleamed, and between them Harry saw, quite distinctly, the hulking outline of something very big, with wide, gleaming eyes. Harry stepped backward. His legs hit his trunk and he tripped. His wand flew out of his hand as he flung out an arm to break his fall, and he landed, hard, in the gutter. There was a deafening BANG, and Harry threw up his hands to shield his eyes against a sudden blinding light†¦ With a yell, he rolled back onto the pavement, just in time. A second later, a gigantic pair of wheels and headlights screeched to a halt exactly where Harry had just been lying. They belonged, as Harry saw when he raised his head, to a triple-decker, violently purple bus, which had appeared out of thin air. Gold lettering over the windshield spelled The Knight Bus. For a split second, Harry wondered if he had been knocked silly by his fall. Then a conductor in a purple uniform leapt out of the bus and began to speak loudly to the night. â€Å"Welcome to the Knight Bus, emergency transport for the stranded witch or wizard. just stick out your wand hand, step on board, and we can take you anywhere you want to go. My name is Stan Shunpike, and I will be your conductor this eve–â€Å" The conductor stopped abruptly. He had just caught sight of Harry, who was still sitting on the ground. Harry snatched up his wand again and scrambled to his feet. Close up, he saw that Stan Shunpike was only a few years older than he was, eighteen or nineteen at most, with large, protruding ears and quite a few pimples. â€Å"What were you doin’ down there?† said Stan, dropping his professional manner. â€Å"Fell over,† said Harry. â€Å"‘Choo fall over for?† sniggered Stan. â€Å"I didn’t do it on purpose,† said Harry, annoyed. One of the knees in his jeans was torn, and the hand he had thrown out to break his fall was bleeding. He suddenly remembered why he had fallen over and turned around quickly to stare at the alleyway between the garage and fence. The Knight Bus’s headlamps were flooding it with light, and it was empty. â€Å"‘Choo lookin’ at?† said Stan. â€Å"There was a big black thing,† said Harry, pointing uncertainly into the gap. â€Å"Like a dog†¦but massive†¦Ã¢â‚¬  He looked around at Stan, whose mouth was slightly open. With a feeling of unease, Harry saw Stan’s eyes move to the scar on Harry’s forehead. â€Å"Woss that on your ‘ead?† said Stan abruptly. â€Å"Nothing,† said Harry quickly, flattening his hair over his scar. If the Ministry of Magic was looking for him, he didn’t want to make it too easy for them. â€Å"Woss your name?† Stan persisted. â€Å"Neville Longbottom,† said Harry, saying the first name that came into his head. â€Å"So — so this bus,† he went on quickly, hoping to distract Stan, â€Å"did you say it goes anywhere?† â€Å"Yep,† said Stan proudly, â€Å"anywhere you like, ‘long it’s on land. Can’t do nuffink underwater. â€Å"Ere,† he said, looking suspicious again, â€Å"you did flag us down, dincha? Stuck out your wand ‘and, dincha?† â€Å"Yes,† said Harry quickly. â€Å"Listen, how much would it be to get to London?† â€Å"Eleven Sickles,† said Stan, â€Å"but for firteen you get ‘ot chocolate, and for fifteen you get an ‘ot-water bottle an’ a toofbrush in the color of your choice.† Harry rummaged once more in his trunk, extracted his money bag, and shoved some gold into Stan’s hand. He and Stan then lifted his trunk, with Hedwig’s cage balanced on top, up the steps of the bus. There were no seats; instead, half a dozen brass bedsteads stood beside the curtained windows. Candles were burning in brackets beside each bed, illuminating the wood-paneled walls. A tiny wizard in a nightcap at the rear of the bus muttered, â€Å"Not now, thanks, I’m pickling some slugs† and rolled over in his sleep. â€Å"You ‘ave this one,† Stan whispered, shoving Harry’s trunk under the bed right behind the driver, who was sitting in an armchair in front of the steering wheel. â€Å"This is our driver, Ernie Prang. This is Neville Longbottom, Ern.† Ernie Prang, an elderly wizard wearing very thick glasses, nodded to Harry, who nervously flattened his bangs again and sat down on his bed. â€Å"Take ‘er away, Ern,† said Stan, sitting down in the armchair next to Ernie’s. There was another tremendous BANG, and the next moment Harry found himself flat on his bed, thrown backward by the speed of the Knight Bus. Pulling himself up, Harry stared out of the dark window and saw that they were now bowling along a completely different street. Stan was watching Harry’s stunned face with great enjoyment. â€Å"This is where we was before you flagged us down,† he said. â€Å"Where are we, Ern? Somewhere in Wales?† â€Å"Ar,† said Ernie. â€Å"How come the Muggles don’t hear the bus?† said Harry. â€Å"Them!† said Stan contemptuously. â€Å"Don’ listen properly, do they? Don’ look properly either. Never notice nuffink, they don’.† â€Å"Best go wake up Madam Marsh, Stan,† said Ern. â€Å"We’ll be in Abergavenny in a minute.† Stan passed Harry’s bed and disappeared up a narrow wooden staircase. Harry was still looking out of the window, feeling increasingly nervous. Ernie didn’t seem to have mastered the use of a steering wheel. The Knight Bus kept mounting the pavement, but it didn’t hit anything; lines of lampposts, mailboxes, and trash cans jumped out of its way as it approached and back into position once it had passed. Stan came back downstairs, followed by a faintly green witch wrapped in a traveling cloak. â€Å"‘Ere you go, Madam Marsh,† said Stan happily as Ern stamped on the brake and the beds slid a foot or so toward the front of the bus. Madam Marsh clamped a handkerchief to her mouth and tottered down the steps. Stan threw her bag out after her and rammed the doors shut; there was another loud BANG, and they were thundering down a narrow country lane, trees leaping out of the way. Harry wouldn’t have been able to sleep even if he had been traveling on a bus that didn’t keep banging loudly and jumping a hundred miles at a time. His stomach churned as he fell back to wondering what was going to happen to him, and whether the Dursleys had managed to get Aunt Marge off the ceiling yet. Stan had unfurled a copy of the Daily Prophet and was now reading with his tongue between his teeth. A large photograph of a sunken-faced man with long, matted hair blinked slowly at Harry from the front page. He looked strangely familiar. â€Å"That man!† Harry said, forgetting his troubles for a moment. â€Å"He was on the Muggle news!† Stanley turned to the front page and chuckled. â€Å"Sirius Black,† he said, nodding. â€Å"‘Course ‘e was on the Muggle news, Neville. Where you been?† He gave a superior sort of chuckle at the blank look on Harry’s face, removed the front page, and handed it to Harry. â€Å"You oughta read the papers more, Neville.† Harry held the paper up to the candlelight and read: BLACK STILL AT LARGE Sirius Black, possibly the most infamous prisoner ever to be held in Azkaban fortress, is still eluding capture, the Ministry of Magic confirmed today. â€Å"We are doing all we can to recapture Black,† said the Minister of Magic, Cornelius Fudge, this morning, â€Å"and we beg the magical community to remain calm.† Fudge has been criticized by some members of the International Federation of Warlocks for informing the Muggle Prime Minister of the crisis. â€Å"Well, really, I had to, don’t you know,† said an irritable Fudge. â€Å"Black is mad. He’s a danger to anyone who crosses him, magic or Muggle. I have the Prime Minister’s assurance that he will not breathe a word of Black’s true identity to anyone. And let’s face it — who’d believe him if he did?† While Muggles have been told that Black is carrying a gun (a kind of metal wand that Muggles use to kill each other), the magical community lives in fear of a massacre like that of twelve years ago, when Black murdered thirteen people with a single curse. Harry looked into the shadowed eyes of Sirius Black, the only part of the sunken face that seemed alive. Harry had never met a vampire, but he had seen pictures of them in his Defense Against the Dark Arts classes, and Black, with his waxy white skin, looked just like one. â€Å"Scary-lookin’ fing, inee?† said Stan, who had been watching Harry read. â€Å"He murdered thirteen people?† said Harry, handing the page back to Stan, â€Å"with one curse?† â€Å"Yep,† said Stan, â€Å"in front of witnesses an’ all. Broad daylight. Big trouble it caused, dinnit, Ern?† â€Å"Ar,† said Ern darkly. Stan swiveled in his armchair, his hands on the back, the better to look at Harry. â€Å"Black woz a big supporter of You-Know-‘Oo,† he said. â€Å"What, Voldemort?† said Harry, without thinking. Even Stan’s pimples went white; Ern jerked the steering wheel so hard that a whole farmhouse had to jump aside to avoid the bus. â€Å"You outta your tree?† yelped Stan. â€Å"‘Choo say ‘is name for?† â€Å"Sorry,† said Harry hastily. â€Å"Sorry, I — I forgot –â€Å" â€Å"Forgot!† said Stan weakly. â€Å"Blimey, my ‘eart’s goin’ that fast†¦Ã¢â‚¬  â€Å"So — so Black was a supporter of You-Know-Who?† Harry prompted apologetically. â€Å"Yeah,† said Stan, still rubbing his chest. â€Å"Yeah, that’s right. Very close to You-Know-‘Oo, they say†¦anyway, when little ‘Arry Potter got the better of You-Know-‘Oo† — Harry nervously flattened his bangs down again — â€Å"all You-Know-‘Oo’s supporters was tracked down, wasn’t they, Ern? Most of ’em knew it was all over, wiv You-Know-‘Oo gone, and they came quiet. But not Sirius Black. I ‘eard he thought ‘e’d be second-in-command once You-Know-‘Oo ‘ad taken over. â€Å"Anyway, they cornered Black in the middle of a street full of Muggles an’ Black took out ‘is wand and ‘e blasted ‘alf the street apart, an’ a wizard got it, an’ so did a dozen Muggles what got in the way. ‘Orrible, eh? An’ you know what Black did then?† Stan continued in a dramatic whisper. â€Å"What?† said Harry. â€Å"Laughed,† said Stan. â€Å"Jus’ stood there an’ laughed. An’ when reinforcements from the Ministry of Magic got there, ‘e went wiv em quiet as anyfink, still laughing ‘is ‘ead off. ‘Cos ‘e’s mad, inee, Ern? Inee mad?† â€Å"If he weren’t when he went to Azkaban, he will be now,† said Ern in his slow voice. â€Å"I’d blow meself up before I set foot in that place. Serves him right, mind you†¦after what he did†¦Ã¢â‚¬  â€Å"They ‘ad a job coverin’ it up, din’ they, Ern?† Stan said. â€Å"‘Ole street blown up an’ all them Muggles dead. What was it they said ‘ad ‘appened, Ern?† â€Å"Gas explosion,† grunted Ernie. â€Å"An’ now ‘e’s out,† said Stan, examining the newspaper picture of Black’s gaunt face again. â€Å"Never been a breakout from Azkaban before, ‘as there, Ern? Beats me ‘ow ‘e did it. Frightenin’, eh? Mind, I don’t fancy ‘is chances against them Azkaban guards, eh, Ern?† Ernie suddenly shivered. â€Å"Talk about summat else, Stan, there’s a good lad. Them Azkaban guards give me the collywobbles.† Stan put the paper away reluctantly, and Harry leaned against the window of the Knight Bus, feeling worse than ever. He couldn’t help imagining what Stan might be telling his passengers in a few nights’ time. â€Å"‘Ear about that ‘Arry Potter? Blew up ‘is aunt! We ‘ad ‘im ‘ere on the Knight Bus, di’n’t we, Ern? ‘E was tryin’ to run for it†¦Ã¢â‚¬  He, Harry, had broken wizard law just like Sirius Black. Was inflating Aunt Marge bad enough to land him in Azkaban? Harry didn’t know anything about the wizard prison, though everyone he’d ever heard speak of it did so in the same fearful tone. Hagrid, the Hogwarts gamekeeper, had spent two months there only last year. Harry wouldn’t soon forget the look of terror on Hagrid’s face when he had been told where he was going, and Hagrid was one of the bravest people Harry knew. The Knight Bus rolled through the darkness, scattering bushes and wastebaskets, telephone booths and trees, and Harry lay, restless and miserable, on his feather bed. After a while, Stan remembered that Harry had paid for hot chocolate, but poured it all over Harry’s pillow when the bus moved abruptly from Anglesea to Aberdeen. One by one, wizards and witches in dressing gowns and slippers descended from the upper floors to leave the bus. They all looked very pleased to go. Finally, Harry was the only passenger left. â€Å"Right then, Neville,† said Stan, clapping his hands, â€Å"whereabouts in London?† â€Å"Diagon Alley,† said Harry. â€Å"Righto,† said Stan. â€Å"‘Old tight, then.† BANG. They were thundering along Charing Cross Road. Harry sat up and watched buildings and benches squeezing themselves out of the Knight Bus’s way. The sky was getting a little lighter. He would lie low for a couple of hours, go to Gringotts the moment it opened, then set off — where, he didn’t know. Ern slammed on the brakes and the Knight Bus skidded to a halt in front of a small and shabby-looking pub, the Leaky Cauldron, behind which lay the magical entrance to Diagon Alley. â€Å"Thanks,† Harry said to Ern. He jumped down the steps and helped Stan lower his trunk and Hedwig’s cage onto the pavement. â€Å"Well,† said Harry. â€Å"‘Bye then!† But Stan wasn’t paying attention. Still standing in the doorway to the bus) he was goggling at the shadowy entrance to the Leaky Cauldron. â€Å"There you are, Harry,† said a voice. Before Harry could turn, he felt a hand on his shoulder. At the same time, Stan shouted, â€Å"Blimey! Ern, come ‘ere! Come ‘ere!† Harry looked up at the owner of the hand on his shoulder and felt a bucketful of ice cascade into his stomach — he had walked right into Cornelius Fudge, the Minister of Magic himself. Stan leapt onto the pavement beside them. â€Å"What didja call Neville, Minister?† he said excitedly. Fudge, a portly little man in a long, pinstriped cloak, looked cold and exhausted. â€Å"Neville?† he repeated, frowning. â€Å"This is Harry Potter.† â€Å"I knew it!† Stan shouted gleefully. â€Å"Ern! Ern! Guess ‘oo Neville is, Ern! ‘E’s ‘Arry Potter! I can see ‘is scar!† â€Å"Yes,† said Fudge testily, â€Å"well, I’m very glad the Knight Bus picked Harry up, but he and I need to step inside the Leaky Cauldron now†¦Ã¢â‚¬  Fudge increased the pressure on Harry’s shoulder, and Harry found himself being steered inside the pub. A stooping figure bearing a lantern appeared through the door behind the bar. It was Tom, the wizened, toothless landlord. â€Å"You’ve got him, Minister!† said Tom. â€Å"Will you be wanting anything? Beer? Brandy?† â€Å"Perhaps a pot of tea,† said Fudge, who still hadn’t let go of Harry. There was a loud scraping and puffing from behind them, and Stan and Ern appeared, carrying Harry’s trunk and Hedwig’s cage and looking around excitedly. â€Å"‘Ow come you di’n’t tell us ‘oo you are, eh, Neville?† said Stan, beaming at Harry, while Ernie’s owlish face peered interestedly over Stan’s shoulder. â€Å"And a private parlor, please, Tom,† said Fudge pointedly. â€Å"‘Bye,† Harry said miserably to Stan and Ern as Tom beckoned Fudge toward the passage that led from the bar. â€Å"‘Bye, Neville!† called Stan. Fudge marched Harry along the narrow passage after Tom’s lantern, and then into a small parlor. Tom clicked his fingers, a fire burst into life in the grate, and he bowed himself out of the room. â€Å"Sit down, Harry,† said Fudge, indicating a chair by the fire. Harry sat down, feeling goose bumps rising up his arms despite the glow of the fire. Fudge took off his pinstriped cloak and tossed it aside, then hitched up the trousers of his bottle-green suit and sat down opposite Harry. â€Å"I am Cornelius Fudge, Harry. The Minister of Magic.† Harry already knew this, of course; he had seen Fudge once before, but as he had been wearing his father’s Invisibility Cloak at the time, Fudge wasn’t to know that. Tom the innkeeper reappeared, wearing an apron over his nightshirt and bearing a tray of tea and crumpets. He placed the tray on a table between Fudge and Harry and left the parlor, closing the door behind him. â€Å"Well, Harry,† said Fudge, pouring out tea, â€Å"you’ve had us all in a right flap, I don’t mind telling you. Running away from your aunt and uncle’s house like that! I’d started to think†¦but you’re safe, and that’s what matters.† Fudge buttered himself a crumpet and pushed the plate toward Harry. â€Å"Eat, Harry, you look dead on your feet. Now then†¦You will be pleased to hear that we have dealt with the unfortunate blowing-up of Miss Marjorie Dursley. Two members of the Accidental Magic Reversal Department were dispatched to Privet Drive a few hours ago. Miss Dursley has been punctured and her memory has been modified. She has no recollection of the incident at all. So that’s that, and no harm done.† Fudge smiled at Harry over the rim of his teacup, rather like an uncle surveying a favorite nephew. Harry, who couldn’t believe his ears, opened his mouth to speak, couldn’t think of anything to say, and closed it again. â€Å"Ah, you’re worrying about the reaction of your aunt and uncle?† said Fudge. â€Å"Well, I won’t deny that they are extremely angry, Harry, but they are prepared to take you back next summer as long as you stay at Hogwarts for the Christmas and Easter holidays.† Harry unstuck his throat. â€Å"I always stay at Hogwarts for the Christmas and Easter holidays,† he said, â€Å"and I don’t ever want to go back to Privet Drive.† â€Å"Now, now, I’m sure you’ll feel differently once you’ve calmed down,† said Fudge in a worried tone. â€Å"They are your family, after all, and I’m sure you are fond of each other — er — very deep down.† It didn’t occur to Harry to put Fudge right. He was still waiting to hear what was going to happen to him now. â€Å"So all that remains,† said Fudge, now buttering himself a second crumpet, â€Å"is to decide where you’re going to spend the last two weeks of your vacation. I suggest you take a room here at the Leaky Cauldron and†¦Ã¢â‚¬  â€Å"Hang on,† blurted Harry. â€Å"What about my punishment?† Fudge blinked. â€Å"Punishment?† â€Å"I broke the law!† Harry said. â€Å"The Decree for the Restriction of Underage Wizardry!† â€Å"Oh, my dear boy, we’re not going to punish you for a little thing like that!† cried Fudge, waving his crumpet impatiently. â€Å"It was an accident! We don’t send people to Azkaban just for blowing up their aunts!† But this didn’t tally at all with Harry’s past dealings with the Ministry of Magic. â€Å"Last year, I got an official warning just because a house-elf smashed a pudding in my uncle’s house!† he told Fudge, frowning. â€Å"The Ministry of Magic said I’d be expelled from Hogwarts if there was any more magic there!† Unless Harry’s eyes were deceiving him, Fudge was suddenly looking awkward. â€Å"Circumstances change, Harry†¦We have to take into account†¦in the present climate†¦Surely you don’t want to be expelled?† â€Å"Of course I don’t,† said Harry. â€Å"Well then, what’s all the fuss about?† laughed Fudge. â€Å"Now, have a crumpet, Harry, while I go and see if Tom’s got a room for you.† Fudge strode out of the parlor and Harry stared after him. There was something extremely odd going on. Why had Fudge been waiting for him at the Leaky Cauldron, if not to punish him for what he’d done? And now Harry came to think of it, surely it wasn’t usual for the Minister of Magic himself to get involved in matters of underage magic? Fudge came back, accompanied by Tom the innkeeper. â€Å"Room eleven’s free, Harry,† said Fudge. â€Å"I think you’ll be very comfortable. just one thing, and I’m sure you’ll understand†¦I don’t want you wandering off into Muggle London, all right? Keep to Diagon Alley. And you’re to be back here before dark each night. Sure you’ll understand. Tom will be keeping an eye on you for me.† â€Å"Okay,† said Harry slowly, â€Å"but why?† â€Å"Don’t want to lose you again, do we?† said Fudge with a hearty laugh. â€Å"No, no†¦best we know where you are†¦I mean†¦Ã¢â‚¬  Fudge cleared his throat loudly and picked up his pinstriped cloak. â€Å"Well, I’ll be off, plenty to do, you know†¦Ã¢â‚¬  â€Å"Have you had any luck with Black yet?† Harry asked. Fudge’s finger slipped on the silver fastenings of his cloak. â€Å"What’s that? Oh, you’ve heard – well, no, not yet, but it’s only a matter of time. The Azkaban guards have never yet failed†¦and they are angrier than I’ve ever seen them.† Fudge shuddered slightly. â€Å"So, I’ll say good-bye.† He held out his hand and Harry, shaking it, had a sudden idea. â€Å"Er — Minister? Can I ask you something?† â€Å"Certainly,† said Fudge with a smile. â€Å"Well, third years at Hogwarts are allowed to visit Hogsmeade, but my aunt and uncle didn’t sign the permission form. D’you think you could –?† Fudge was looking uncomfortable. â€Å"Ah,† he said. â€Å"No, no, I’m very sorry, Harry, but as I’m not your parent or guardian –â€Å" â€Å"But you’re the Minister of Magic,† said Harry eagerly. â€Å"If you gave me permission†¦Ã¢â‚¬  â€Å"No, I’m sorry, Harry, but rules are rules,† said Fudge flatly. â€Å"Perhaps you’ll be able to visit Hogsmeade next year. In fact, I think it’s best if you don’t†¦yes†¦well, I’ll be off. Enjoy your stay, Harry.† And with a last smile and shake of Harry’s hand, Fudge left the room. Tom now moved forward, beaming at Harry. â€Å"If you’ll follow me, Mr. Potter,† he said, â€Å"I’ve already taken your things up†¦Ã¢â‚¬  Harry followed Tom up a handsome wooden staircase to a door with a brass number eleven on it, which Tom unlocked and opened for him. Inside was a very comfortable-looking bed, some highly polished oak furniture, a cheerfully crackling fire and, perched on top of the wardrobe — â€Å"Hedwig!† Harry gasped. The snowy owl clicked her beak and fluttered down onto Harry’s arm. â€Å"Very smart owl you’ve got there,† chuckled Tom. â€Å"Arrived about five minutes after you did. If there’s anything you need, Mr. Potter, don’t hesitate to ask.† He gave another bow and left. Harry sat on his bed for a long time, absentmindedly stroking Hedwig. The sky outside the window was changing rapidly from deep, velvety blue to cold, steely gray and then, slowly, to pink shot with gold. Harry could hardly believe that he’d left Privet Drive only a few hours ago, that he wasn’t expelled, and that he was now facing two completely Dursley-free weeks. â€Å"It’s been a very weird night, Hedwig,† he yawned. And without even removing his glasses, he slumped back onto his pillows and fell asleep. How to cite Chapter 3 The Knight Bus, Essay examples

Wednesday, April 29, 2020

The Driving Way Essay Example For Students

The Driving Way Essay Selecting a career path is the easiest decision one can make; I have chosen five in the nine years since high school. The problem is selecting a path and following it to completion. When I returned to school for my most recent career path, I worked hard and did well for the first several months. Then, I started staying out late with a young lady, and the amount of time that I applied to school decreased by an order of magnitude. After several weeks with her, it was apparent that my grades were going to be bad. I told my father that I was not doing well in school, and that I was going to quit school to work full time again. He surprised me when he replied, Do you remember the first time that I let you drive?Although I vaguely remembered the event, I said, Of course I do. We will write a custom essay on The Driving Way specifically for you for only $16.38 $13.9/page Order now Father then ask, Do you still drive as poorly as you did that day?Sensing one of the old mans long-winded speeches about to start, I harshly said, No, whats your point?After my abrasive reply, Father shook his head and started reading a book. Although I did not want to hear his speech, I could not keep from wondering what he wanted to say. I thought about the Saturday morning that my father let me drive for the first time. He drove me to a stretch of road so long and straight that you could see it converge in the horizon. He pulled over and told me to swap seats with him. Despite being nervous, I wasted no time getting behind the wheel. Timidly, I put the car in drive and pulled into the road. Father then said, All that you have to do is point it straight and keep it between the lines. With fathers advice about driving in mind, I carefully lined the car between the lines and headed down the road. I did well for the first several minutes. Then, my mind wandered, and I started paying less attention to the road. In a few seconds, I felt a thump and heard the car hit gravel. I overreacted and jerked the wheel; the car slid sideways, and suddenly we stopped. I was sure that my father was going to yell about my poor driving, but he quietly said, Son, let me clarify my advice to you. It is not only about starting in the right direction and then forgetting what you are doing. It is about always paying attention to where you are and where you want to be. It is about making subtle corrections; if a correction is to big, it will always send you out of control. After I pondered the old mans driving advice, I decided not to quit school. I stopped seeing the young lady, and dropped two classes—which left time for me to concentrate on my remaining classes. Because of the correction, I finished the semester on the deans list. Almost one year has passed since then, and I am still going down the same path; I pay attention and make minor corrections when corrections are needed. Acceptance Essays

Friday, March 20, 2020

Censorship Essays (888 words) - Freedom Of Expression, Censorship

Censorship Essays (888 words) - Freedom Of Expression, Censorship Censorship CENSORSHIP Censorship and the ideology supporting it reiterates concepts from ancient times. In early Greek civilization, Socrates was accused of worshipping strange gods and corrupting the minds of the youth. He preferred to sacrifice his life rather than accept the censorship of his teachings. Socrates advocated free discussion, and is the first person in recorded history to formulate a philosophy of intellectual freedom. Ancient Roman society endorsed that only members of the Senate, or persons of vast authority, enjoyed the privilege of free speech. However, the extensive Roman Empire could not have remained intact for four centuries if it had not maintained a tolerant attitude toward the diverse religions and cults of the races it ruled. In our own country, the American Revolution branded the beginning of an era with an emphasis on toleration and liberty the Age of Enlightenment. It affected all aspects of society, from religious belief and political life, to science and literature. The De claration of Independence, the Bill of Rights and the U.S. Constitution sanctioned that restraint on publication is unconstitutional. Such repression is only justified in extreme cases, such as times of war. In modern times, censorship refers to the examination of books, plays, periodicals, films, television and radio programs, news reports and the internet for the purpose of suppressing material thought to be objectionable or offensive. Censorship can be defined as the supervision and control of the information and ideas that are circulated among the people within a society. It concerns objectionable materials, such as those which may be considered to be immoral, obscene, treasonable or injurious to national security. The rationale of censorship is that it is necessary for the protection of basic social institutions: the family, the church and the state. It is a guardian of morals, and intrudes in many aspects of society: it supervises our communications, suppresses our freedom of speech, alters and edits our media and reduces the knowledge base that we can gain access to. It is claimed that permissiveness in the arts and mass media debases the public taste and corrupts all sense of dec ency. One aspect of censorship is that it omits some of our freedoms of speech when addressing a large group of people. For example, no person has the right to shout Fire! in a crowded theatre when no fire is present, or urge an angry mob to riot. This, as stipulated by Congress, would be a clear and present danger to the peace and security of the community. In some local communities, school boards have exerted pressure on publishers to omit certain areas of text relating to various sensitive issues, such as evolution, the biblical account of creation, or discussions of racial or religious groups. When publishers, authors or broadcasters trespass the political or moral boundaries set by law, they may be subject to fines, imprisonment and confiscation of their publication. The U.S. film industry practices a form of self-censorship. The Motion Picture Association of America imposed on its constituents a system of film classification. The Federal Communications Commission implemented v ague rules for television and radio about program content. They restrict the use of explicit language and direct references to sex. Religious, ethnic and racial groups have attempted to prevent plays, movies, and television programs because of elements they find offensive. In terms of my own opinions concerning censorship, I do not believe that it should be completely eliminated from our society. Instead of the materials we have access to being filtered and limited, I believe that the information should be available to those who choose to, and are mature enough to view it. One aspect I feel strongly about is that any individual should be able to openly criticize, through speech or publication, any government or public official. If we do not have the right to question or criticize our authority figures, than there is nothing to set our democratic society apart from that of a dictatorship. I do not believe that censorship should interfere with our correspondence, privacy, family or with our freedom of thought, religion or opinion. In terms of how censorship should be dealt with in our classroom, I think that omitting all profanity from music selection would eliminate a huge portion

Wednesday, March 4, 2020

Get the 411 on the 809 Area Code Scam

Get the 411 on the 809 Area Code Scam Viral alerts circulating since 1996 warn consumers not to comply with telephone, pager, or email requests to dial phone numbers beginning with the area code 809, 284, or 876. Its a real scam, but less prevalent than the alerts suggest. These alerts have been circulating since the mid-1990s. Heres an example of one that appeared on Facebook in February 2014: VERY COSTLY NEW AREA CODE:- READ AND PASS ALONG0809 Area CodeWe actually received a call last week from the 0809 area code. The woman said Hey, this is Karen. Sorry I missed you- get back to us quickly. I have something important to tell you. Then she repeated a phone number beginning with 0809. We did not respond, this week, we received the following e-mail:Do Not DIAL AREA CODE 0809,0284, and 0876 from the UK .This one is being distributed all over the UK ... This is pretty scary, especially given the way they try to get you to call. Be sure you read this and pass it on. They get you to call by telling you that it is information about a family member who has been ill or to tell you someone has been arrested, died, or to let you know you have won a wonderful prize, etc.. In each case, you are told to call the 0809 number right away. Since there are so many new area codes these days, people unknowingly return these calls.If you call from the UK you will apparently be charged a minimu m of  £1500 per-minute, and youll also get a long recorded message. The point is, they will try to keep you on the phone as long as possible to increase the charges.WHY IT WORKS:The 0809 area code is located in the Dominican Republic ....The charges afterwards can become a real nightmare. Thats because you did actually DID make the call. If you complain, both your local phone company and your long distance carrier will not want to get involved and will most likely tell you that they are simply providing the billing for the foreign company. Youll end up dealing with a foreign company that argues they have done nothing wrong.Please forward this entire message to your friends, family and colleagues to help them become aware of this scam. Analysis: Somewhat True Variants of the 809 area code scam alert have circulated via email, online forums, and social media since 1996. Albeit in an exaggerated and not entirely accurate fashion, the warnings describe a real scam in which consumers are tricked into dialing international phone numbers and racking up unexpected long-distance charges (though nowhere near the whopping $24,100 total or  £1500 per minute reported in these rumors). According to ATT, the scam has become less prevalent in recent years thanks to the preventative efforts of long distance carriers. The 809 area code scam can work because a few regions outside the U.S., including the Caribbean and Canada, can be dialed directly without the usual 011 international prefix. 809 is the area code of the Dominican Republic. 284 is the area code of the British Virgin Islands. 876 is the area code of Jamaica. Since these numbers arent subject to laws outside those countries, theres no legal requirement to inform callers in advance of any special rates or fees. Perpetrators have conned victims into dialing the numbers by leaving messages claiming that a relative has been injured or arrested, an unpaid account must be settled, or a cash prize can be claimed, etc. ATT advises that consumers always check the location of unfamiliar area codes before dialing. This can be done by querying the NANPA website (North American Numbering Plan), checking an area code locator website or simply Googling the area code and viewing the top result.

Sunday, February 16, 2020

Organizational Trends Discussion Essay Example | Topics and Well Written Essays - 500 words

Organizational Trends Discussion - Essay Example This type of organization creates superior organizational capabilities that help sustain high performance driven results. HPO's tend to be organized around operational business processes and its human resource policies are designed to enhance employee's motivation, flexibility and knowledge. The main characteristics of an HPO are: employee involvement where decision making is delegated at all organizational levels, self directed work teams provide empowerment for organizational teams to be involved in planning, performing and evaluating their own performance, integrated production technologies to combine technology, resources and knowledge to better serve the organization's needs, and a total quality management philosophy to everyday business. â€Å"High performance organizations strive to deliver superior service, quality and financial performance† (Schermerhorn & Hunt & Osborn). HPO's tend leaders in their respective industries have successful track records and they have the inherent flexibility and resourcefulness to respond to a rapidly changing and dynamic business environment. This type of organization tends to have a clear emphasis towards intellectual capital or the sum total of knowledge, expertise and dedication that is part of the organization's workforce.

Monday, February 3, 2020

Extra Credit Essay Example | Topics and Well Written Essays - 250 words - 2

Extra Credit - Essay Example On researching the ecological and agricultural characteristics in the Denver area it is found that the peculiar climatic condition experiencing there is between desert climate and humid climate. Hence the climatic condition prevailing there is considered as mild evapotranspiration climate. Since this city is at high altitude this peculiar climatic condition provide the quality of the Mediterranean weather such as dry summer and wetter winter. It is considered that the city has 79 official neighborhoods. Hence the residents of this metropolitan area are mainly the neighborhood communities. The features of these neighborhoods vary each other and they include large skyscrapers, twentieth century houses and modern styled twenty first century buildings. The neighborhoods which are closer to the Denver city comprises of denser buildings which are old styled. The developments of the neighborhoods which are not closer to the concerned city had taken place immediately after Second World War. The buildings at these areas were constructed with modern materials and hence they appeared in high style. Still farther neighborhoods were with suburban characteristics and the people in that area could be recognized by means of their features. Majority of the neighborhoods have parks and other modern facilities and these are considered as the key peculiarities of these neighborhoods. The important neighborhoods of Denver city are Lower Down Town, Union Station Neighborhood, Washington Park, Capitol Hill, Highland Cherry etc. All these neighborhoods have very important roles in the metropolitan developments of the Denver city. Parks are the main peculiarities of the Denver city. As per the survey conducted in 2006 this metropolitan city has more than 200 parks in its credit which vary from mini parks to giant ones. All these parks are with beautiful landscape architects. Since the Denver city is situated at high altitude these are no scarcity for mountain

Saturday, January 25, 2020

Insulin and Erythropoietin Production

Insulin and Erythropoietin Production Insulin is a protein (polypeptide) discovered in 1921 by Banting with the pancreas being the site of its production. It is made up of 51 amino acids, divided into 2 chains; A and B, bonded by disulfide linkages. Chain A is made up of 21 amino acids with an intra-disulphide linkage, while chain B is made up of 30 amino acids (4). Why Insulin? Insulin is important in glucose metabolism, and is being used for the treatment of Diabetes mellitus; a metabolic disorder of glucose in the body. Initially, Insulin from animals was used to treat this disorder however nowadays synthesized human Insulin is being used, this is because; it is fast absorbed by the body, it has less allergic reactions, it contains less impurities, and it produces good results (3). Recombinant process of producing Insulin Synthetic Insulin was first produced in 1983 through genetic Engineering, which involve extraction of the human DNA (1), once extracted, the gene for Insulin is isolated, and enzymes are used to cut it. The gene is then cut using enzymes and put into the plasmid of a vector, where in most cases E. coli plasmid is used. Since Insulin contains two chains, two pieces of DNA are extracted, and the genes for the two chains are linked to ÃŽ ² galactosidase enzyme of the bacteria. The plasmids formed are then inserted into a host cell E. coli and sealed using another enzyme called ligase. And the host on replicating produces the enzymes each containing one of the two chains each. Production is followed by extracting and purifying the chains which are mixed in a reaction to reconstitute the disulphide bridges (1). ESCHERICHIA COLI AS RECOMBINANT INSULIN HOST Entero-bacillus, gram-negative E. coli is about 1 2ÃŽ ¼m, it can survive in the presence/absence of oxygen, and it also grows in an optimum pH and temperature of 7.0 and 37oC respectively. It utilizes glucose as its major carbon source and can also use other carbon sources like pyruvate, glycerol, acetate, and other sugars. K-12 and B strains are mostly used in the laboratory (20) Reasons for choosing E. coli Genetic Engineering technologies were developed using E. coli as a role organism, and so, the genetics of E. coli are well known among other microorganisms, as such its the most used organism for the production of different proteins (14). Moreover E. coli has a well known safety and production abilities, stable plasmid, controllable promoter, cheaper and easily cultured (6), E. coli also has fast growth rate, its easy to handle, and has well known fermentation skills and the ability to produce high protein content (14). That is why most of the proteins licensed recently by FDA and EMEA, were produced in E. coli (5). With these, and the fact that Insulin is a simple polypeptide (protein) which does not require glycosylation for its bioactivity and stability, E. coli carrying the plasmids for production of insulin will be used as the host for the production of Insulin Strain and plasmids: BL21 strain containing the pMYW-A and pMYW-B plasmids and temperature repressor ÃŽ »-c1857, will be used for insulin production (21). Growth strategy The various growth strategies that will be used to grow E. coli in order to make it happy and produce the desired product (11) include: Medium: E. coli needs nutrients like carbon, nitrogen and others; thus a carbon source; glycerol will be provided since its cheaper and more soluble than glucose (12), a source of nitrogen in the form of ammonium sulphate will also be provided. However such nutrients in large quantities can inhibit the growth of E. coli, as such a defined medium that contain optimum concentrations 20gl-1 glycerol and 2gl-1 ammonium sulphate will be used (11). The medium will also consist of the following; 3gl-1 KH2PO4, 1gl-1 MgSO4.7H2O, 0.8gl-1 citrate, and 6gl-1 K2HPO4 (23). Some trace elements will also be added to the medium. (23) Process and culture-strategies: E. coli will be grown submerged in a sterile controlled stirred tank reactor, and fed-batch will be used as the growth strategy so as to avoid accumulation of acetate which can be inhibits its growth, and reduce the production of the insulin (18). The growth strategy will be divided into two; initially batch mode will be used to initiate growth, after which the fed-batch exponential feeding will be used to produce the insulin (21). After adapting the medium and feeding method, oxygen transfer rates (OTRs) had to be increased through a suitable bioreactor design and over-head pressure (16). Large scale reactors usually reach high ORTs using air and normal aeration pressure, and so the oxygen partial pressure (pO2) will be increased by adding pure oxygen to the air-stream entering the reactor, thus increasing its oxygen transfer rates (16) DO will be maintained at 40% of air saturation and aeration rate at 1vvm. Foaming arising due to large number of cells and high aeration-rates will be solved by use of impellers for stirring simultaneously at 300rpm and the use of antifoam (ucolub N115) (16, 21). The process temperature and pH will be maintained at 30oC and 6.8 respectively so as to avoid partial proteolysis of the insulin protein. Bioreactor Design: Bioreactor vessel is usually cylindrical and made up of stainless steel. It is composed of impeller for stirring, Air sparger is placed at the bottom of the vessel for introduction of air, it has some inlets for introduction of acid/alkali for pH control and also for introduction of antifoams, nutrients and inoculum; It is also has pH, DO and temperature probes for sensing (22), Microbial activity during fermentation usually produces heat, so the bioreactor design must allow for removal of heat, and this can be achieved by cooling with jackets and coils (16) Bioreactors must also be designed in a way that it can withstand high temperature and pressure and to allow cleaning-up and sterilizing (22). Growth analysis Temperature, pH, DO, foam, partial oxygen and carbon dioxide pressures, will be analysed on-line, other parameters like biomass, will be analysed by using optical density (OD600) and dry cell weight (offline). Cell viability will be analysed by using flow cytometry, the concentrations of substrates and metabolites by enzymatic methods while insulin will be analysed using electrophoresis methods like SDS-PAGE, and ELISA, while its purity will be determined by HPLC (8). Limitations/Problems There are several problems that may arise during processing and can limit the use of this organism for Insulin production, these are; Poor secretion because of the structure of its membrane (and tough cell wall), small amount of foldases, chaperones and increased concentrations of proteases, leading to low productivity (7). Solutions to this problem include all measures taken to increase quality of secretion and production such as: Use of secretion systems like the system of ÃŽ ±-haemolysin (7) co-expression after co-cloning of foldases and chaperones (13) Improving the rates of gene-expression and using proteases deficient mutants like BL21 (18). use of E. coli mutants that are deficient of cell-wall (12) Limited post translational-modifications; including disulfide-linkage formation, which is important for the insulin stability and biological activity (9). Solutions to this problem include; Production of insulin with altered amino acid sequences through genetic engineering (9) Using E. coli mutants to enhance the formation of disulfide linkages e.g. Origami (15) iii. Exporting proteins into the periplasm which has disulphide bonding mechanisms (19). Codon biases; due to large quantities of exact transfer-RNAs found in E. coli, the codons in the human-genes are often different from those that are found in this organism. This results in inefficient expression of some of these rare codons by the organism resulting in an unexpected protein synthesis termination or wrong incorporation of the amino acids (12). This problem can be solved by replacing codons that are rare in the desired gene by codons that are often found in the E. coli and by co-expressing the rare transfer-RNAs (15). Acetate is usually formed as a by-product, and is inhibitory to growth of the cells (20). Solution is by using a fed-batch feeding method and by limiting DO level (11). Another problem is that large proteins are often obtained in an insoluble form (5); forming aggregates called inclusion bodies; IBs (20). This can be solved by adjustment of temperature, increasing the strength of the promoter, adjusting the number of plasmids, concentrations of the inducer, and the composition of the media (9). Erythropoietin EPO EPO is a glycoprotein that is produced in the renal cortex of the kidney (10, 11). It has also being shown to be present in the brain, spleen, liver and the lungs (7, 17). It is made up of 165 amino acids of about 18kDa (25), with a number of carbohydrates linked to the polypeptide through O and N glycosidic-bonds giving the glycoprotein a total weight of 34kDa.Two disulphide linkages hold the molecule together (15) and the carbohydrates are responsible for the stability of the glycoprotein in-vivo,and increasing its half-life in the body (24). Why EPO? EPO functions to regulate the amount of red blood cells (RBC) in the blood by controlling the proliferation and differentiation of its immature cells to mature cells (1, 2, 22,). It is also involved in the growth and formation of blood vessels, and healing of wounds (6), it functions in the brain is not clear, but studies showed the glycoprotein to have some protective effects (18). Because of these functions EPO has being used in the treatment of anaemia caused by kidney failure and other causes (25). Recombinant production of EPO Despite its importance, EPO in body is found in very small amounts and mostly in the urine (4), as such there is the requirement to produce EPO in large amounts, this leads to the work of isolating the glycoprotein from the urine (12, 21), and was used to identify its amino acid sequences, and synthesis of its DNA (9, 12), furthermore the human erythropoietin genes were cloned by Lin et al. (17), and consequently recombinant human EPO (rhuEPO) was produced in 1985 using CHO cells (14, 16). Chinese -Hamster- Ovary (CHO-Cells) as rhuEPO host: These are epithelial cells derived from the ovary of Chinese hamster (a mammal). They grow well in culture and looks like cobble stones. The cells usually attach to a surface available but can be grown in suspension (20). CHO cells are grown best at 37oC and at pH 7.4; they are cultured in a suitable complex medium which can support their growth for many generations (20). CHO cell lines are now available from cell culture collections like the American type culture collection; ATCC. Moreover human EPO expression plasmids are now also commercially available, and are usually used for production of EPO using the CHO cells (27). Reasons for choosing CHO-cells Karthik et al. (13) showed that CHO-cells are being used extensively in the industries for the production of many proteins, because they have demonstrated, to possess some qualities like: They can modify biological products post-translationally; Proteins produce in CHO-cells have high glycosylation quality making them compatible and stable (13) Safety of the product; Studies in 1989 have shown that most viruses do not multiply in CHO-cells (13) Ability to adapt easily and be grown in suspension (13). Products can now be purified to contain less contaminant (13). CHO cells have being used for a long time; as such much data has being accumulated for regulatory reasons (13). They are easy to manipulate genetically (13). The isolation of cells deficient in Dihydrofolate-reductase enzymes leads to stable clones selection and genes amplification to increase production (13). With all these, and the fact that EPO is a glycoprotein that requires glycosylation for its stability and activity, recombinant CHO cells are chosen to produce EPO. Cell lines and plasmids: Cell lines which have the capability of glycosylating proteins (Pro-5), harboring the pGEX-HET-puro expression plasmid, will be used to produce the recombinant human erythropoietin (27). Growth strategy Medium: Complex culture medium will be provided with; Glucose as a source of carbon and energy, Amino acids as source of nitrogen, Salts will be included to make the solution isotonic Vitamins and hormones will be added as co-factors Serum is usually added to the culture medium to enhance the growth of the cell (20), but has the following disadvantages: It chemicals are not defined and can cause cell growth inconsistency between batches (20) It is very expensive (20) The serum may contain proteins which can be difficult to separate and purify from the proteins secreted by the cells during downstream processing (20) It increases foaming and can be a source of contamination by viruses. (20) Therefore a serum-free (SF) media (16) will be used for the growth of the E. coli. Process and culture-strategies: The cells will be grown adherent on micro-carriers in a sterile controlled packed bed reactor, and perfusion method of production where some amounts of the medium is removed and replaced by fresh one and the cells are grown slowly will be used (28); because it was found to improve the glycosylation of the proteins more than fed-batch where there is fast growth of cells, (8). Before, many processes were run in a simple batch method, but nowadays, Perfusion or fed-batch methods are mostly employed and higher products are now realized (22). The production will be carried out in two stages; the growth stage and the production stage. Normally stirring will be kept at 100 to 150 rpm, foaming will be avoided by adding Pluronic F68 (16).Temperature will be maintained at 37oC initially during growth and then reduced to 33oC during production, as was shown to increase the overall protein production, while maintaining the quality of the glycoprotein (3, 26). pH w ill be kept at 7.1 initially and then reduced to 6.8 (8, 26), by passing CO2 gas to the culture or by addition of concentrated sodium-bicarbonate solution in low quantities, because CO2 is also toxic to the cells and can also affect the production of EPO (20). In order to avoid the depletion of oxygen, the oxygen transfer rates (OTRs) will be increased above its utilization rate, with a constant supply of pure oxygen and air, while DO will be maintained at 20-50% of air saturation (20). Bioreactor Design: Since the cells are big and fragile, the design of the bioreactor has to be considered. Mammalian cell culture bioreactors are designed with bottoms that are round and are usually made up of glass/stainless steel (20). The impellers are usually marine or pitched blade types fitted at the end of mechanical drives shafts so that both vertical and horizontal mixing are allowed at low stirring-rates (20). Temperature is controlled through coiled pipes or open ended fermenter jacket (20). pH, DO and temperature probes are used for sensing and have both air inlet and outlet for respiration. Growth Analysis Temperature, pH and DO will be monitored on-line, because cells are immobilized, biomass formed cannot be measured directly therefore it will be monitored by measuring rate of glucose consumed daily and the rate of lactate produced (28) Cell viability by flow cytometry, Glucose, glutamine, and lactate concentrations will be analysed using multi-parameter Bio-analytical system (26); while ammonia formed as waste product of amino acid metabolism, will be analysed by colorimetric assay and by the use of detection-kit (26). EPO formed will be analysed using HPLC to determine its purity and its quality by Isoelectric focusing, SDS, and Bradford assay (26). The activity of EPO will be analysed by bioassay and by the use of protein assay-kit (27) Limitations/Problems. There are many limitations associated with CHO cells culture processes and they include; They are fragile and highly sensitive to shear stress caused by agitation and bubble because the cells are large and have only cell membrane (20). This is usually solved using a suitable bioreactor-design and use of Pluronic F68 (20). They need a complex medium including serum which can cause problems in the downstream processing and is expensive (20). Solution to this is by using serum- free media (24, 25). Low yield of proteins have been produced from these cells, the productivity using the microbes being higher than the use of these cells. They also have slow growth rates (13). The problem of low productivity and slow growth rates can be solved through selecting cell lines that are better and optimizing cultural-strategies. Ammonia and lactate are generated during growth and can inhibit growth and also affect glycosylation (8). Solution is by optimizing the strategies of feeding and by monitoring (8). Glycosylation differences may arise from the EPO produced in the CHO-cells and the human EPO as seen in the way the two are sialylated terminally, as a result that the CHO-cells are not able to express an enzyme called alpha-2,6, sialyltransferase (27). Solution is by the use of CHO-cells harboring alpha-2, 6, sialyltransferase-cDNA expression-cassettes (27). REFERENCES: 1. Alcamo, I., DNA Technology; the Awesome-Skill. Farming-dale. New York: Academic Press. (2001). 2. Banting Grolier Electronic publishing www.littletree.com.au/dna.htm accessed on 30/12/2010 3. Carbs information, www.carb-information.com/insulin-synthetic.htm accessed on 30/12/ 2010. 4. Charce, R.E., and Frank, B.H., Research, Production and Safety of Biosynthetic Human Insulin. (1993). www.littletree.com.au/dna.htm accessed on 30/12/2010. 5. Ferrer-Miralles N. Domingo-Espà ­n, J. Corchero, J.L. Và ¡zquez, E. and Villaverde, A. Microb. fact. for recombinant pharmaceuticals, Microbial factories , 8:17, 2009. 6. Fox, S. Improved processes and new capacity for pipeline to commercial production. Biopharmaceutical contract manufacturing, Volume 1 (report). High Tech Business Decisions: San Jose, CA. 2005 7. Genschev, I., Dietrich, G., Goebel, W.,The E. coli alpha-hemolysin secretion system and its use in vaccine development. Trends Microbiol. 10: 39-45. 2002 8. Hewitt C.J., Nebe-von Caron G., Axelsson B., McFarlane C.M, Nienow A.W Studies related to the scale-up of high-cell-density E. coli fed-batch fermentations using multi-parameter flow cytometry: effect of a changing microenvironment with respect to glucose and dissolved oxygen concentration. Biotech. Bioeng. 70: 381-390. 2000 9. Hite P.F, Barnes A.M.J.P.E. Exhuberance over Exubera. Clinical Diabetes 24: 110-114. 2006. 10. Jana, S., Deb, J.K. Strategies for efficient production of heterologous proteins in Escherichia coli. Appl. Microbiol. Biotech. 67: 289-29. 2005. 11. Joseph S., and Raphael F., growing E. coli to high- cell density-A historical perspective on method development Biotech. Advances 23: 345-357 2005. 12. Korz D.J, Rinas U., Hellmuth K, Sanders E.A, Deckwer W.D. Simple fed-batch technique for high cell density cultivation of E. coli. J Biotechnology, 39: 56-65. 1995. 13. Kujau, M.J., Hoischen, C., Riesenberg, D., Gumpert, J. Expression and secretion of functional mini-antibodies McPC603scFvDhlx in cell-wall-less L-form strains of Proteus mirabilis and E. coli: a comparison of the synthesis capacities of L-form strains with E. coli producer strain. Appl. Microbiol. Biotech. 49: 51-58. 1998. 14. Lund, P.A. Microbial molecular chaperones. Advanc. Microbiol. Physiol. 44: 93-140. 2001 15. Makrides S.C. Strategies for achieving high-level expression of genes in Escherichia coli. Microbiol. Rev. 60: 512-5388. 1996. 16. Meyer, H.P. Brass, J. Jungo, C. Klein, J. Wenger, J. and Mommer, R. an emerging Star for Therapeutic and Catalytic Protein Production. Bioprocess International. 2008. 17. Nacelle, G. J. V. and Coppel, R. L. Reshaping Life; Key Issues in Genetic Engineering, Novo-Nordisk Promotional Brochure. Melbourne: Melbourne University Press. 1989. 18. Schmidt, F.R. Recombinant expression systems in pharmaceutical industry. Appl. Microbiol. Biotech. 65:363-37. 2004. 19. Wacker M., Linton D., Hitchen P.G., Nita-Lazar M., Haslam, S.M., North, S.J., Panico M., Morris H.R., Dell A., Wren, B.W., Aeb, M. N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli. Science 298:1790-1793. 2002. 20. Demain, L. A., and Vaishnav, P. Production of recombinant proteins by microbes and higher organisms. Biotech.Advan. 27: 297-306. 2009. 21. Schmidt, M., Raman Babu, K., Khanna, N., Marten, S., Rinas, U., Temperature- induced production of recombinant human insulin in high cell density culture of recombinant Escherichia Coli. Journal of Biotech. 68:71-83. 1999. 22. Ratledge, C. and Kristiansen, B. Basic biotechnology. Cambridge: Cambridge university press. 2001. 23. Tabandeh, F., Shojaosadati, S.A., Zomorodipour, A., Khodabandeh, M., Sanati, M.H., Yakhchali, B. Heat induced production of human growth hormone by high cell density cultivation of recombinant E. coli. Biotech. Letters. 26: 245-250. 2004.

Friday, January 17, 2020

Pros and Cons of Genetic Engineering in Plants Essay

Less tillage needed, especially with crops containing herbicide tolerance transgenes, therefore conserves fertility through minimizing soil damage through compression. |GE agriculture claims low tillage weed control: this can be achieved by ending the practice of monoculture and instead introducing proper crop rotations designed specifically to combat the weeds of the particular locality. Monoculture creates a weed paradise. | All countries face problems caused by alien species accidentally or deliberately introduced into a new environment (e.g. prickly pear in Australia). The main factor permitting this is international travel, but nobody has suggested that this should be banned. The problem of alien species is manageable, as would be the problem of genetic pollution caused by spread of seeds or pollen. As regards pollen contamination from GM varieties and the call for compensation for growers of non-GM or organic varieties whose crops are contaminated, if one is to be fair one migh t reasonably expect growers of non-GM and organic varieties to compensate growers of GM crops if they are contaminated with non-GM or organic pollen. |Genetic pollution from transgenes spreads into other organisms through pollen, seeds and microbial processes. It is fundamentally different from other forms of pollution because once the genes are out, they can’t be recalled. The best example of pollen contamination is provided by the canola seed, which was multiplied in Canada. It was officially confirmed in May 2000 that this seed was contaminated with unapproved GM canola seed and accidentally shipped to UK and other countries. By then it had been planted in Europe and large acreages of the young crop had to be destroyed. According to Advanta, the contamination occurred because of cross-pollination in Canada, where the seed was produced. The nearest source of GM contamination was 4 kilometers away.| Organic farming has long accepted accidental contamination from herbicide sp rays from neighboring farms. If there is concern about GMOs, DNA tests can be carried out.|Risks destroying organic farming, which rules out the use of GM organisms. Who will compensate organic farmers for the extra surveillance and analysis, which will be needed to ensure that the organic food chains remain free of GMOs?| The Starlink debacle is indeed a lesson that the GM food producers will learn from. Identity Preservation Systems are being put in place, verified by DNA analysis, to ensure that GM and non-GM supplies are kept separate.|The massive contamination in 2000 of the USA corn (maize) crop and human food chain by Starlink, a variety that is not approved for human consumption, shows that genetic pollution from transgenic crops to non-transgenic crops and food is inevitable. Starlink maize produces the Cry9C protein, which may be a human allergen. Two other major contaminations of ordinary seed (maize and canola seed) with GM seed have already occurred leading to emergency recalls of the product.| Reduces labor costs. |Sustainable organic agriculture creates much needed jobs in depressed rural economies.| Environmentally relatively benign herbicides are used and less of them. Opposing GM crops forces farmers to use herbicide resistant varieties which have not been made by GM such as those resistant to sulphonylurea herbicides which more readily give rise to herbicide resista nt weeds.|Promotes â€Å"agribusiness†, therefore more herbicide use. Herbicides are responsible for much illness in farm workers and contaminate drinking water.| Enhances biodiversity by allowing weeds to continue growing for longer thus providing nutrition for animals. After weed kill a mulch forms which hosts a thriving population of insects, arthropods etc.|The total herbicides used with herbicide tolerant crops kill all weeds thus reducing biodiversity in the field.| No insecticidal sprays needed on crops that have insecticidal Bacillus thuringiensis (Bt)-toxin genes engineered into them. Plants with Bt or other insecticidal genes are likely to give rise to lower levels of mycotoxins in the final food product. Less insect damage means less opportunity for fungi to infect the plant and bring toxic substances.|As with weed control, control of insect damage is achievable with properly designed crop rotation and other forms of good husbandry such as intercropping. Healthy pl ants not imbalanced by chemical fertilizers build up their own defenses against insect attack. | GM plants are carefully tested for environmental and ecological impact, including their effects on earthworms and beneficial insects. Bt crops target only insects, which attack the crop. Future insect resistance genes will be engineered to express in leaves and stem rather than in pollen and seed. There is already evidence that the Bt gene is expressed less in Bt corn pollen than in leaves/stems therefore the risk to butterflies (e.g. Monarch) through pollen drift onto their food plants (e.g. milkweed for Monarch) is diminished. |In relation to population variance, sample sizes in lab and field tests (e.g. of earthworms) are sometimes too low to detect even large effects. Insecticidal crops containing the gene for Bacillus thuringiensis (Bt)-toxin kill beneficial organisms such as bees, ladybirds, lacewings & butterflies (e.g. through pollen). The Bt plant remains falling to the ground are harmful to earthworms and other members of soil fauna. Bt toxins are secreted into soil from Bt plant roots and are toxic to lepidoptera in the soil (Stotzky, et al. Nature 402, 480 (1999)). The specific targeting and elimination of one insect pest has led to other pestiferous insect species moving into the ecological niche created by the disappearance of the first species. Getting rid of one problem simply created another. If Bt toxin transgenes spread to wild relatives of crop plants the wild plants may also develop resistance to insect herbivores. This could lead to the affected wild plants becoming invasive weeds.| The problem of resistance to Bt toxin and other toxins engineered into crops can be countered by planting suitably sized ‘refuges’ of a non-GM variety of the crop at suitable intervals within the crop. The interbreeding of the wild population with the Bt-exposed potentially resistant population will dilute out the genetic trait and thus prevent it building up.|Putting the Bt toxin gene in the crop exposes the pest to the toxin for longer, thus allowing natural genetic resistance to the toxin to develop in the pest. So-called refuge systems do not work, partly because breeding cycles in the differing pest populations are not synchronized. Refuges of up to 40% of the acreage are having to be recommended and this is not practical or popular for farmers. The build up of Bt toxin resistance threatens to render ineffective an insecticide long used by organic agriculture. Increased use of biopesticides in transgenic crops deprives the ecosystem of one of its natural pest controls thereby putting at risk its ability to restore equilibrium after being upset by abnormal conditions. | Helps solve the problem of world hunger by creating varieties which will make more efficient utilization of scarce land and give higher yields because of better pest resistance, nutrient utilization etc.|World hunger will not be solved by technological means. It is a problem of inequitable distribution of wealth and corrupt governments. Reduces yields (e.g. cotton, soybeans and sugar beet in some areas).| If herbicide resistance spreads to weed populations it can be combated with another herbicide with a different active ingredient. The ecological and agricultural threat of a GM plant is no more than a non-GM invasive (exotic) species such as kudzu or purple l oosestrife. Although improved crop yields can be engineered by genetically modifying plants, there is ecological concern over whether these plants are likely to persist in the wild in the event of dispersal from their cultivated habitat. The results of a long-term study of the performance of transgenic crops in natural habitats on four different crops (canola seed, potato, maize and sugar beet) which were grown in 12 different habitats and monitored over a period of 10 years show that in no case were the genetically modified plants found to be more invasive or more persistent than their conventional counterparts. (M. J. CRAWLEY, S. L. BROWN, R. S. HAILS, D. D. KOHN & M. REES. Biotechnology: Transgenic crops in natural habitats Nature 409, 682 – 683 (2001)  © Macmillan Publishers Ltd)|Enhances spread of herbicide resistance to wild weed populations because the necessary genes are in the pollen, which can then pollinate wild relatives of the crop plant. This could create â₠¬Ëœsuperweeds’ especially if ‘gene stacking’ of several different transgenes occurs. Spread of transgenes is also caused by birds, animals & machinery carrying the seed to other locations (e.g. canola seed on Ailsa Craig isle, 10 miles from Scottish mainland) Increased weediness of GM crops is already beginning to show. In 1999, in Alberta, Canada canola seed volunteers (unwanted crop plants coming up the following year) resistant to three different herbicides have been discovered. A series of chemical and DNA tests confirm the weeds in farmer Tony Huether’s field near Sexsmith are resistant to Roundup ®, Liberty ® and Pursuit ® herbicide chemicals. Invasive species of plants can remain relatively unproblematic in a region for many years and then suddenly take a hold so much so that they become an economically significant nuisance. For this reason, the ecological impact of GM crops will be difficult to predict in the long term, i.e. over several decades. | Most cultivars are unlikely to survive amongst wild plant populations and those with herbicide resistance that escape will have no advantage from the herbicide resistance trait unless that particular herbicide is used. Such volunteers can be controlled with other herbicides.|Transgenic herbicide resistant cultivars could escape into the wild and become problematic ‘volunteers’ in agriculture. These volunteers will require increased use of more toxic herbicides.| Is a sustainable agriculture, because it reduces chemical inputs as well as fuel inputs for farm machinery.|Unsustainable — based on greed not need. Helps chemical agriculture to proliferate. The only sustainable agriculture for the future is organic (including biodynamic & permaculture).| Quicker and more precise than traditional breeding.|Breeding takes place outside the proper c ontext, i.e. in the laboratory, therefore the crops are so weakened that they need to have the environment of the laboratory (soil sterilization, artificial fertilizers and pesticides) brought to them in the field. Transgenic lines are unstable and can lead to crop failures (e.g. GM cotton in USA).| A greater range of distinct disease-resistant varieties can be created so that the farmer has a wide choice and can plant a mixture of several varieties of the same crop in the same field to insure against disease attack. Disease resistance traits can be rapidly introduced to cultivars, e.g. rice, thus keeping ahead of the changing pattern of disease in a particular locality.|Because of the huge investment in GM crops, the necessarily increased emphasis on single high-yielding varieties reduces genetic diversity within the crop itself. This can lay the crop open to massive losses when disease strikes.| Novel drought and salt-tolerant cultivars can be created (important for Third World Co untries).|Sustainable organic plant breeding can develop novel varieties properly suited to a locality perfectly satisfactorily.| Any royalties or technology fees are more than compensated for by advantages including higher yields and easier, therefore less expensive, husbandry.|No seed saving by the farmer is permitted. The farmer has to pay royalties to the biotech company. This undermines a traditional agricultural practice and particularly threatens peasant farming in developing countries. GM crops add to the tendency of modern chemical agriculture to undermine the autonomy of farmers and turn them into tractor drivers or machine minders for large transnational corporations.| New varieties are tested for toxicity more than any crop plants have ever been in the past, therefore they are likely to be safer. Jimmy Clark, a professor of ruminant nutrition in Animal Sciences at the University of Illinois at Urbana-Champaign, reviewed the results from 23 research experiments, which wer e conducted over the past four years at universities throughout the United States, Germany and France. In each study, separate groups of chickens, dairy cows, beef cattle and sheep were fed either genetically modified corn or soybeans or traditional corn or soybean as a portion of their diet. Each experiment independently confirmed that there is no significant difference in the animals’ ability to digest the genetically modified crops and no significant difference in the weight gain, milk production, milk composition, and overall health of the animals when compared to animals fed the traditional crops. Clark concluded, â€Å"Based on safety analyses required for each crop, human consumption of milk, meat and eggs produced from animals fed genetically modified crops should be as safe as products derived from animals fed conventional crops.† Clark added that approximately 70% of the genetically modified soybeans produced in the world and 80% of the genetically modified corn produced in the United States are used as animal feed. â€Å"Since these genetically modified crops were grown beginning in 1996, they have been fed to livestock and no detrimental effects have been reported,† Clark said. (University of Illinois at Urbana-Champaign, News Release, Apr il 2001).|Increases herbicide residues in the food because the herbicide is applied later in the growing season and closer to harvest | The issue of spread of antibiotic resistance from GM crops containing antibiotic resistance marker genes is unproven. If it is a problem at all it is likely to be small compared with the induction of antibiotic resistance through profligate use of antibiotics in animal nutrition, veterinary and medical practice.|Spreads antibiotic resistance to microorganisms in the environment, and then to pathogenic bacteria.| More profit for the farmer, seed producer and biotech company shareholder.|No demonstrable benefit to the consumer. | Crops producing ‘nutraceuticals’ can be engineered, i.e. food additives that have a nutritional benefit bordering on a pharmaceutical benefit, e.g. modified edible oils. The vitamin content of plants can be enhanced by GM. Plants which previously did not contain a particular vitamin can now be made to produce lar ge amounts of it (e.g. Vitamin A ‘golden’ rice). The aim of the GM Vitamin A rice project is not to achieve ideal levels of vitamin A intake through this source but to augment the extremely low intakes which lead to blindness and death of hundreds of thousands of people a year (Prof. Dr. Ingo Potrykus, statement, February 2001). |In 1999, Deutsche Bank issued a report advising investors to avoid investing in GM crop technology (agribiotech). A balanced diet of fresh fruit & vegetables plus cereals and protein is all that is necessary. ‘Nutraceuticals’ are a sticking plaster (band aid) attempt to remedy fundamentally unhealthy diets. Existing food sources provide adequate daily intakes of vitamins provided they are eaten in sufficient amounts and the vitamins are not destroyed in the processing or cooking. Vitamin-enhanced GM plants are an unnecessary technical solution to a problem, which does not exist. Even with Vitamin A GM rice a normal daily intake of 300 gram of rice would, at best, provide 8% percent of the vitamin A needed daily.| The ‘killer genes’ of the technology protection system (‘terminator technology’) allows the seed producer’s intellectual property (patent) to be protected by a biological rather than litigious method.|No seed saving by the farmer is permitted. The farmer has to pay royalties to the biotech company. This undermines a traditional agricultural practice and particularly threatens peasant farming in developing countries.| The increased cho ice of modern high-yielding cultivars to farmers allows diversification to keep ahead of economic, climatic and plant disease trends.|The possibility of further globalization of crop varieties that GE offers through the introduction of traits necessary for introduction into new regions of the globe erodes cultural diversity – i.e. traditionally, different crops and varieties are grown by different cultures. Genetic engineering works towards global uniformity, i.e. globalization of Western/Northern culture. There used to be far greater choice of crop varieties for farmers, sometimes hundreds of varieties of a particular crop in a given region, but this diversity is falling at an alarming rate because of the industrialization of farming under pressure from the agrochemical industry. This will be accelerated by biotech agribusiness.| GE allows the creation of plants that produce vaccines, pharmaceuticals or enhanced pharmaceutical raw materials. |GE is already used to produce ph armaceuticals in microorganisms in the much safer containment conditions of biotechnology factories. It should not be taken out into the environment thus putting the environment at risk. In any case, much of the pharmaceutical production, which would be created, is designed to treat diseases caused by industrialization and urbanization, which could be better treated not by a genetic fix but by changing lifestyles and environment.| Novel food crops are tested for genetic stability (breeding true), ‘substantial equivalence’, nutritive properties, toxicity and allergenicity. It is well known that conventional breeding can introduce increased levels of natural plant toxins into a new variety or can modify its digestibility or nutritiousness. Furthermore, certain organic crops have been shown to have higher levels of toxic substances, e.g potatoes.|GE introduces unpredictable toxic or allergenic effects into food plants (e.g. Brazil nut gene in transgenic soybeans). ‘Substantial equivalence’ is a political-commercial concept rather than a scientific one. GM plants are not genetically stable. For instance, the number of copies of an inserted gene changes through later generations of the GM plant. | This technology is completely new to the insurance industry. It is natural that insurers will be cautious about it. However, when they realize that the risks are no worse than with introduced ali en species that are dealt with by conventional methods of weed control, the problem of insurance will disappear. No amount of research under containment conditions will reveal how a GM plant will behave when grown en masse in the open field.|As the degree of escape of genes from GM crops is unpredictable, they can’t be recalled once they have escaped and they could multiply in the wild, some insurance underwriters have stated that such risks are uninsurable. There should be a moratorium on experiments in the open until the safety of the GM plant is fully tested under containment conditions. | Plant pathogens need not be used in making GM plants. The genes can be blasted into plant cells using a ‘gene gun’, which fire microparticles of metal coated with the DNA of interest.|Plant pathogens such as Agrobacterium tumefaciens (literally ‘cancer causing’) are used to shuttle genes into plants and viral gene sequences such as cauliflower mosaic virus promo ter are used to make the genes express themselves once in the plant. The pathogens could recombine with their natural equivalents in the plant thus risking unpredictable outbreaks of plant disease.| Bioprospecting has gone on since very ancient times. There is no reason why an organism, which just happens to be at a particular location of the globe, should be in the sole ownership of the people living there. Agreements can be entered into in order to protect the traditional usages of indigenous peoples.|Steals genetic commons from peasant farmers and indigenous peoples (biopiracy by the rich North, e.g. neem tree & basmati rice).| Biopolymers can be produced in GM plants allowing the manufacture of biodegradeable plastics (e.g. PHBV, Biopol), which are also sustainable because they are not made from fossil fuels. |No comment|